Exogenous collagen cross-linking recovers tendon mechanical integrity in an acute tear model.
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چکیده
INTRODUCTION: Previous testing of various collagen cross-linking agents showed potential to increase stiffness and failure behavior as well as reduce hysteresis and creep behavior in rat tail tendon fascicles [1]. Based on these results, we hypothesized that exogenous collagen cross-linking might be a candidate for reinforcing injured or healing tendons or to halt progression of tendon tears. The goal of this study was to implement a clinically relevant tendon tear model to investigate tear propagation under repetitive loading as well as to quantify the repercussion of exogenous collagen cross-linking on tear progression.
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